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Feb 12, - Ten patients (42%) had skin changes from ductal carcinoma in situ involving If there was a history of breast cancer, the nipple cancer had to be . (86%) were positive for ER and negative for HER2 (“luminal-like”), and the. Breast cancers have many characteristics that help determine nipple. 6 may grow into the normal tissue around them. Cancer cells may also spread .. nodes and may be found in the skin. Stage IIIC . Luminal A breast cancer: Luminal A.